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HMF, an intermediate of the Maillard reaction, is also reported to exhibit antioxidant, antischemic, hemorheological, and anti-tyrosinase effects

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Although Woods lamp examination remains useful to determine whether most of the pigmentation is in the epidermis or in the dermis, studies using laser confocal microscopy have demonstrated that all melasma are mixed, suggesting a common pathophysiology [2]

However, the specific oral bioavailability percentage, the plasma concentration-time profile, and whether enteric coating meaningfully changes these parameters have not been published in human pharmacokinetic studies

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