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However, the exacerbation of age-related mitochondrial oxidative stress did not affect the decline of skeletal muscle respiratory function confirming that NFE2L2 is not exclusive but part of signaling pathways that are deranged during aging [106]

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Endpoints and assessments The primary endpoint was change in HbA 1c from baseline to week 26, and the confirmatory secondary endpoint was change in body weight (kg) from baseline to week 26