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Rose, SR, Lustig RH, Burghen GA, Burstein SR, Pitukcheewanont P, Broome DC, Hodnicak V, Beaver K, Hollingsworth Y, Walker S: Diagnosis of ACTH deficiency: low dose and one-hour ACTH test versus overnight metyrapone test

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Macroscopic Assessment The depth of destruction in articular cartilage was evaluated according to the measures described by Pelletier et al 32 using a four-point scale (0 = normal-appearing surface, 1 = negligible fibrillation or a minor yellowish discoloration of the surface, 2 = destruction spread out into the superficial or central layers only, 3 = destruction that spread into the deep layers, and 4 = destruction that spread to the subchondral bone)