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Specifically, chondrocytes exposed to ferric ammonium citrate (FAC) exhibit increased expression of FTH1 and reduced levels of transferrin receptor 1 (TfR1) and hepcidin, whereas ferroportin (FPN1) expression remains unchanged ( 3.3.2 Fenton reactions and the bidirectional effects of iron homeostasis imbalance Free Fe + participates in the Fenton reaction, leading to the generation of hydroxyl radicals (OH), which represents a crucial step in initiating the lipid peroxidation chain reaction ( 3.3.3 Local iron homeostasis and the joint microenvironment Pathological changes such as increased vascular permeability or microbleeding in subchondral bone can also lead to local iron deposition
10.1074/jbc.RA118.001975 60 WidmannC.DolciW.ThorensB
Tirzepatide versus semaglutide in patients with type 2 diabetes
No benefit in terms of the risk of HF hospitalization was observed with oral semaglutide, as well as with efpeglenatide (43, 44)
Independent risk factors for atrial fibrillation in a population-based cohort
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