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Specifically, reduced IL-12 hampers Th1 cell differentiation and macrophage activation, reduced IL-2 compromises T-cell proliferation, and reduced IFN- impairs intracellular defense [19]

Almost all AD patients exhibit erratic sleep patterns, nocturnal staying awake, and daytime sleepiness (Hatfield, 2004)

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Furthermore, specific deletion of Atg7 in the mouse colonic epithelium results in significant changes to fecal microbiota composition, including an increase in total bacterial counts and an enrichment of species such as Clostridium leptum , Eubacterium cylindroides , and Bacteroides fragilis [142]

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