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doi: 10.1016/j.psj.2023.103337 109

97 A third factor has to do with the difference in how dietary arginine and endogenous arginine produce NOwhich is so confusing that its been labeled the arginine paradox. The paradox is that when someone is healthy, taking supplemental arginine doesnt increase the steady-state, constitutive NO supplied by arginine made in the body (which is what body builders look for when taking arginine)

In this theory, principal drug represents a basic component of the prescription, and its main role is to target the cause of the disease or the main syndrome

Inability to recover properly after exertion is one of the most disabling symptoms of ME/CFS