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Cell Death Dis 15(1):24
Glutathione S-transferase activity of leukemic cells as a prognostic factor for response to chemotherapy in acute leukemias
However, this effect might be independent of changes in visceral fat accumulation since previous studies have demonstrated that the hepatic glucose production is decreased in healthy individuals following acute administration of both native GLP-1 ( de novo lipogenesis and reduces levels of lipolysis-induced FFA and triglyceride-derived toxic metabolites ( Insulinotropic effect As alluded above, patients with NAFLD, in whole its spectrum including cirrhotic individuals, show a reduced incretin effect
"Our findings extend previous anecdotal safety signals and provide more systematic evidence to inform clinical awareness of this potential adverse effect," write the researchers
Some researchers also suggest it may interact with neurons via the Mitogen-Activated Protein Kinase (MAPK) pathway, which regulates intercellular signaling [15]
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