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The TMAO treatment induced the hypertrophy of cultured cardiomyocytes and expression of hypertrophic markers such as atrial natriuretic peptide (ANP) and beta-myosin heavy chain (-MHC) that was demonstrated to be mediated via TGF-/Smad3 signaling that had been identified in the development of cardiac hypertrophy and fibrosis

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Together, we can translate those insights into future therapy development, innovations in care delivery, and greater patient outcomes," said Brian Bradbury, vice president of Observational Research at Amgen

Semaglutide works by targeting the GLP-1 receptor pathway