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By Drug Class, the GLP-1 Agonist segment is anticipated to witness the fastest growth, registering a CAGR of 35.9% over the forecast period By GLP-1 Agonist - Drug Class, the Semaglutide segment accounted for the largest market share of 59.3% in 2024

In recent GLP-1RA trials focusing on patients with obesity, favourable effect on worsening heart failure in HFpEF patients was indicated to be modulated by baseline BMI [32], although the underlying mechanisms that explain the cardiovascular and renal benefits may not necessarily be due to weight loss alone

This dual action produces superior blood sugar control and weight loss compared to semaglutide alone

Additionally, the lack of robust biomarkers to monitor specific cell death pathways in real-time (e.g., circulating free DNA (cfDNA) or mixed lineage kinase domain-like protein (MLKL)) hinders the development of precision medicine approaches

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