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Glucagon-like peptide-1 receptor signaling in the ventral tegmental area reduces alcohol self-administration in male rats
A true relative risk anywhere in that range would be considered statistically significant, but the practical implications differ dramatically between the low and high ends
After 72 weeks: Participants taking 5 mg of tirzepatide lost 15% of their starting body weight on average Those taking 10 mg lost an average of 19.5% Those taking the highest dose, 15 mg, lost an average of 20.9% Another phase 3 clinical trial studied the efficacy of once-daily orforglipron in people with obesity and found that it resulted in significant weight loss compared to placebo
The SELECT trial further showed that once-weekly semaglutide reduced first-event MACE by 20% in adults with obesity and prior cerebrovascular disease, extending cardiovascular protection beyond diabetes [319, 320]
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