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GLP-1s, or Glucagon-Like Peptide-1 receptor agonists, are a class of medications primarily used to manage blood sugar levels in people with type 2 diabetes
Currently, the most popular GLP1-based monotherapy, Semaglutide, controls blood sugar by promoting insulin secretion and induces a lasting sense of fullness to reduce appetite
But while appetite falls, your body still requires protein, vitamins, minerals, amino acids, electrolytes and essential fats whether youre hungry or not
Although physiologic leptin replacement lowers blood glucose levels only slightly, it fully normalizes elevated plasma glucagon and corticosterone levels and reverses the increased hepatic expression of gluconeogenic enzymes characteristic of rats with uncontrolled diabetes (German et al., 2010)