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Additionally, gagunin D, a highly oxygenated diterpenoid from the marine sponge Phorbas sp., was also found to exhibit anti-melanogenic properties by downregulating the expression of proteins associated with melanosome transfer, including Rab27A, MLPH and myosin Va (133)

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Notably, proteins such as MRPS36 and RNF181 were significantly upregulated, while ABCB9 and RIC1 were downregulated

Particularly, GLP-1RAs have greater hypoglycaemic and weight-loss effects and are attracting attention as a means of intervening in obesity, which is the key basis of type 2 diabetes pathogenesis