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178 Consequently, GLP-1 RAs may help restore mitochondrial homeostasis, potentially through AMPK and sirtuin signaling pathways involved in energy sensing, autophagy, and mitochondrial turnover

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The only FDA-approved treatments (disulfiram, naltrexone, and acamprosate) have been modestly successful in treating AUD (e.g., naltrexone reduces relapse rates by 5%) (for a detailed review and meta-analysis 1,2 ), but still are severely under-prescribed

These medications are administered via subcutaneous injection, once weekly for Wegovy and Zepbound

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