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Important Caveats# While the gene expression data is extensive, most evidence comes from in vitro studies and gene expression analyses

For CKD and ESRD patients, in spite of the increased homocysteine levels (average homocysteine level in the general population about 1015 mmol/L versus 2535 mmol/L in uremic patients), the role of homocysteine as a cardiovascular and mortality risk factor is still uncertain and many retrospective and interventional studies resulted in conflicting evidences [8,9,10,11,12]

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Vitamin B12 is a powerhouse nutrient crucial for several bodily functions, including energy metabolism, nerve function, and red blood cell formation

But it can only bind to those receptors if its molecular shape remains intact