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This means it has not undergone FDA review for safety, efficacy, or manufacturing quality , and it cannot be marketed or sold legally as a dietary supplement or medication for human consumption

Many people begin to notice subtle changes within 12 weeks, especially improvements in energy, mood, and motivation

A 2025 case-control study from Vietnam found what researchers described as a U-shaped relationship between B12 intake and cancer risk, with both lower and higher intakes associated with increased risk

detected on nerve conduction velocity (NCV) studies

However, compounded medications do not receive the same FDA approval process as brand drugs