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Our data indicate that aging is regulated by genes encoded in both of our co-evolved mitochondrial and nuclear genomes

Endocrinology 140, 53565363

These vascular changes may lead to interstitial fluid buildup and tissue hypoxia, further driving fibrosis and inflammatory signaling.18 Microvascular dysfunction including increased capillary fragility and permeability contributes to fluid leakage into the interstitial space, resulting in localized edema and a sustained inflammatory state