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Mol Cell Endocrinol 418:4254 Lorenz M, Evers A, Wagner M (2013) Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity

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Key Takeaways Retatrutide is a multifunctional peptide drug that acts as a triple agonist, improving obesity management and metabolic health through regulation of multiple hormonal pathways

17 Both the lipid-soluble GLP-1RAs and small-molecule SGLT-2is were considered to be able to cross the BBB in numerous preclinical trials