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Patients with Leber's hereditary optic neuropathy should avoid cyanocobalamin (hydroxocobalamin is preferred in the UK)

Injection Site: Where on your body the shot is given (often the upper arm, thigh, or buttocks)

Schedule: Daily subcutaneous injections for 816 weeks

Because the peptide occurs naturally in human plasma (at roughly 200 ng/mL in young adults, declining to approximately 80 ng/mL by age 60), topical supplementation essentially restores youthful local concentrations in treated skin

Measurable body composition changes usually become apparent by weeks 2-4, with progressive improvements continuing through weeks 4-12 of consistent use