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Consequently, the oxidized nicotinamide adenine dinucleotide/ATP ratio is depleted, and glyceraldehyde-3-phosphate dehydrogenase is inactivated, leading to the activation of harmful pathways such as the polyol, hexosamine and protein kinase C (PKC) pathways, as well as the subsequent accumulation of advanced glycation end products, resulting in microvascular damage

It comes in pulses, largely overnight, and that rhythm matters

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Intracellular adenosine is generated by AMP dephosphorylation or by hydrolysis of S -adenosylhomocysteine (SAH)

They've done studies, imaging studies of advanced meditators, people who meditate all the time for a long time