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When -oxidation is limited, tumors avoid ferroptosis by (i) reducing PUFA incorporation into membranes 346 , (ii) deploying extramitochondrial ubiquinol recycling to trap lipid radicals 347,348 , and (iii) using the mitochondrial dihydroorotate dehydrogenase-ubiquinone axis to detoxify lipid peroxides in the inner membrane 349

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CulkinsCAdomanisRPhanNRobinsonBSlatonELothropEet alUnlocking the gates: therapeutic agents for noninvasive drug delivery across the blood-brain barrier