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GSTP1 detoxifies arsenic-based drugs by isolating the active site and dimer interface, reacting with cysteine in the presence of sufficient GSH under low GSH conditions (48,49)

However, peripheral neuropathy, a side effect of oxaliplatin, is extremely harsh for the patients and can cause them to give up treatment because of their low quality of life [4,5]

Similar results showing the link between mitochondrial and synaptic dysfunctions affecting synaptic transmission in animal models with 22q11.2 microdeletion were also obtained by other researchers [360, 361]

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In veterinary medicine, milk thistle is one of the few liver support supplements with at least some literature suggesting potential benefits in dogs