More important was liraglutide, marketed as Saxenda, the first GLP-1 receptor agonist approved for obesity
Once in use, most can tolerate room temperature (up to 86F or 30C) for limited periods that vary by product: Wegovy (semaglutide): 28 days at room temperature Ozempic (semaglutide): 56 days at room temperature Zepbound/Mounjaro (tirzepatide): 21 days at room temperature Maintaining proper temperature during international travel is critical to preserve medication efficacy
REDEFINE 1 Results (Phase 3) The landmark trial randomized 3,417 adults to CagriSema 2.4/2.4 mg, semaglutide 2.4 mg alone, cagrilintide 2.4 mg alone, or placebo for 68 weeks (Aronne et al., 2025): The combination significantly outperformed either component alone
This includes tracking blood sugar levels, A1C levels, and weight changes
The slow start is likely to frustrate patients who cannot afford to buy the drugs and comes after an extremely slow rollout of weight-loss injections on the health service
