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This leaves you open to oxidative damage caused by reactive oxygen species (aka free radicals)

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LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al

The choice of B12 form should be made based on individual patient needs

This makes the peptide more suitable for those concerned about cardiovascular health or those who found GH fluid retention problematic