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The prostate gland exhibits unique metabolic features characterized by extraordinary citrate production (up to 180 mM in prostatic fluid) to support sperm energetics, sustained through zinc-mediated inhibition of mitochondrial aconitase(m-ACNT), which blocks citrate-to-isocitrate conversion (71)

And because these medications need to be taken consistently over many years, the costs incurred may surpass that of metabolic surgery after less than a year

If a suboptimal treatment response occurs, another therapy could be selected taking into consideration the patients presentation and the drug profile of the available options

Any disease driven by a harmful protein trapped inside the cell, from certain cancers to some forms of dementia, could one day become a target