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The combination has not been studied across extended timeframes in humans

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139 Additionally, GLP-1RAs have been shown to enhance motor function and prolong survival in amyotrophic lateral sclerosis models, reduce neuronal degeneration, improve behavioral outcomes in Huntingtons disease models, and confer neuroprotection following traumatic brain injury and stroke by mitigating inflammation, reducing cerebral edema, and promoting neurological recovery

31 , 351362 e355 (2020)

Joel Topf, a nephrologist and the author of the staff review of this article, also provided a flowchart of his basic approach to hyponatremia