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People were tested on these weekly doses: 1 milligram (mg) 4 mg (starting at either 2 mg or 4 mg) 8 mg (starting at either 2 mg or 4 mg) 12 mg (starting at 2 mg) The highest dose tested was 12 mg per week , and the gradual increase was important for making side effects easier to handle

Overall, the data highlight the pharmacokinetic challenges of Schisandra chinensis lignans, such as poor solubility and extensive metabolism, necessitating advanced formulation strategies to optimize their therapeutic potential