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This is one reason it's considered a "conditionally essential" nutrient: Your body produces it, but if it doesn't produce enough, your health can be seriously impacted

doi: 10.1016/j.immuni.2015.02.002 380 MurphyMP

This dichotomy might be due to differential basal metabolism and redox status

(PubMed) Still, this is the first place where hype can outrun evidence

Concurrently, downregulation of STAMBP and NEP may impair protein clearance mechanisms, exacerbating proteotoxic stress and -amyloid (A) deposition [52], ultimately triggering neuronal apoptosis, which aligns with our previous observation of reduced MAP2-positive neurons