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Using high concentrations of hydroquinone for extended periods of time can cause an irritant contact skin reaction, and it can also lead to paradoxical darkening of the skin

While in the present study we did not include a group of untreated 5xFAD mice, our previous experience revealed no differences between untreated and IgG-injected mice, neither in the 5xFAD 54 nor DM-hTAU 40 mouse models

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Manda KR, Banerjee A, Banks WA, Ercal N

As AITC treatment led to a similar biological outcome we compared the growth inhibition effects caused by AITC, BSO and a combination of the two chemicals on WT and pad2-1 seedlings