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This, in turn, further exacerbates the accumulation of A and tau, ultimately leading to impaired synaptic plasticity and cognitive impairment ( A number of studies have demonstrated that there are extensive mitochondrial abnormalities in the brains of AD patients and animal models (Swerdlow, 2018)
Their large peptide structure (Figure 1) makes them prone to enzymatic degradation, lowering bioavailability, and can trigger immunogenicity causing anti-drug antibodies (ADAs)
By binding to GLP-1 receptors in the pancreas, brain, and gastrointestinal tract, semaglutide produces several metabolic effects that fundamentally alter how patients experience eating and drinking
Puerarin protects retinal cells against apoptosis by antioxidant mechanisms such as lowering iNOS expression, increasing superoxide dismutase (SOD) activity, and preventing the production of advanced glycation end products (AGEs)