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Extensive studies of these pathways have uncovered upstream regulators (e.g., Legumain, ALR, and Panx1), deepening the mechanistic understanding of renal I/R ferroptosis and expanding therapeutic opportunities for targeting ferroptosis in I/R AKI

Moreover, the UA transportersURAT1, GLUT9, and ABCG2play crucial roles in regulating UA levels, with dysfunctional transporters leading to abnormal serum UA levels, as observed in hypouricemia and hyperuricemia