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Topical application of PEPITEM not only reduced local inflammation but also had systemic effects, such as reducing disease-related splenomegaly and limiting the expansion of CD4+, CD8+, Th1, and Th17 T-cell populations in the spleen

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Transferrin receptor-mediated ROS promote ferroptosis in KGN cells by regulating NADPH oxidase 1/PTEN-induced kinase 1/acyl-CoA synthetase long-chain family member 4 signaling, and the inhibitory effects of TFRC/NOX1/PINK1/ACSL4 signaling on folliculogenesis could be a potential target for PCOS treatment (172)

They are important mediators in regulating the damage that is potentially incurred by biological molecules such as DNA, protein, lipids, and body tissue in the presence of reactive species