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Mitochondrial inhibitor rotenone triggers and enhances neuronal ferroptosis following intracerebral hemorrhage

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As an example, in response to gram-negative LPS, TNF- induces upregulation of macrophage G6PD expression and activity ( 2.3 Effect of G6PD deficiency on innate immune system function and disease Given the role of G6PD in phagocyte effector function, in the 1960s, it was theorized that G6PD deficiency might impact susceptibility to sepsis and meningitis (34)

This is one reason why many of us feel the effects of aging and become susceptible to age-related illnesses as the years pass by