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Importantly, measuring plasma and even tissue levels of various inhibitors may not reveal whether various inhibitors differentially pass across cell membranes and penetrate intracellular compartments

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mTORC1 comprises mTOR, regulatory-associated protein of TOR (raptor), mammalian lethal with sec-13 protein 8 (mlst8), DEP domaincontaining mTOR interacting protein (deptor), and proline-rich Akt substrate of 40kD (pras40) [8, 10]