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In the context of disrupted circadian rhythms, the use of naturalistic lighting optimizes light exposure similar to solar time, allowing for resynchronization of the internal biological clock to the natural light dark cycle (West et al., 2019)

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Most patients receive it once daily, often in the morning to coincide with the bodys natural metabolic cycle

N Engl J Med 349:16051613 Upchurch GR Jr, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr, Loscalzo J (1997) Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase