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Hexarelin does this through a calcium/PKC cascade while blunting somatostatin's inhibitory signal, and Ipamorelin is considered more selective because it does not meaningfully raise cortisol or prolactin alongside GH

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J Biol Chem, 1993

A first step in evaluating these new approaches and their probability of success may be to align the time course of useful AD-associated biomarkers with the posited treatment strategy