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Toxicity: Adverse effects to SAMe are rare but may include inappetence, vomiting, lethargy, and agitation after initial treatment

After undergoing an IPL sun spot treatment, patients might notice a darkening of treated areas initially

European J Clin Investig 33(5):370375 Kuo P, Schroeder R (1995) The emerging multifaceted roles of nitric oxide

Biochemistry 2005, 44 (41), 1345713466

A case report found that taking very high doses of over 5 grams of extended-release niacin can lead to metabolic acidosis, a buildup of acid in body fluids, as well as acute liver failure both of which can be fatal ( Keep in mind that these potentially deadly side effects are associated with taking exceptionally high doses of vitamins