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It is converted to coenzyme B12 in the body and in this form facilitates the conversion of homocysteine to methionine (methylcobalamin) and plays an important role in converting methylmalonyl-coenzyme A to succinyl-Co-A (fatty acid and amino acid metabolism)

de Assis LVM, Kinker GS, Moraes MN, Markus RP, Fernandes PA, Castrucci AML (2018) Expression of the circadian clock gene bmal1 positively correlates with antitumor immunity and patient survival in metastatic melanoma

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Moreover, environmental factors, such as heavy metals, also contribute to excessive ROS