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Some researchers exploring tesofensine for weight management are interested in compounds that provide mild stimulant effects alongside appetite suppression, though the long-term safety profile of such approaches remains under investigation

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For example, mulberry leaf extract has been shown to alleviate obesity by upregulating Hsd11b1 expression in WAT, thereby modulating lipid metabolism and inflammatory pathways (42)

Diabetes 2014;63:33463358 [DOI] [PubMed] [Google Scholar] 18

Patients on tirzepatide also reduced their waist circumference by an average of 18.4 centimeters, compared to 13.0 centimeters on semaglutide (Source: SURMOUNT-5 Trial, Wharton et al., NEJM 2025)