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This, in turn, means doctors will be able to make more informed choices about the best medication to prescribe to patients, Reitano said "If that list is outdated to reality, then you're going to write a prescription assuming that the patient is able to get access to it," Reitano said

Current evidence suggests that if back pain occurs during treatment, it is more likely coincidental or related to indirect factors rather than a direct pharmacologic effect of the medication

This is harder to quantify but worth noting

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While there is no scientific evidence recommending against taking B12 at night, because of its role in energy production, it can elicit a stimulatory effect in some people, as do the other B vitamins