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The role of the extracellular matrix in cancer stemness

Losing too much muscle mass can lead to: Decreased Strength Less muscle directly reduces strength, affecting both physical fitness and basic daily function

These changes occurred before the increase in THDA levels, indicating that the loss of BDNF-TrkB signalling and upregulation of GSTO2 happens before the hyperdopaminergic state, as with the Trkb Penk -KO mice, supporting that GSTO2 increase is more likely a cause of neurodegeneration than a consequence of it

Other risk factors include not eating enough iodine and carrying excess weight