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In addition, the increased expression and activity of NOX and xanthine oxidase and NOS becoming uncoupled and structurally unstable also lead to increased ROS production [8]

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29 The reason for this difference is not apparent apart from the fact that H 2 O 2 levels were measured in young SHR and in whole kidney homogenates in this study, whereas in the above studies measurements were made in cells in vitro

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