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The blood-brain barrier, a selective membrane, exacerbates this problem by limiting the passage of certain therapeutic substances, such as polyphenols, into the central nervous system (Carecho et al., 2024)

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However, the side products of the copper redox cycling, particularly hydroxyl radicals produced via the Harber-Weiss reaction, are among the most reactive and damaging forms of reactive oxygen species (ROS) 35

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