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A 5mg vial reconstituted with 5mL bacteriostatic water yields the same 1000mcg/mL concentration as a 1mg vial with 1mL

For both Zepbound and Retatrutide, there are concerns about: Pancreatitis (inflammation of the pancreas) Gallbladder problems Thyroid tumors (Zepbound includes a warning about medullary thyroid carcinoma based on animal studies) Low blood sugar, especially if combined with other diabetes medications People with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 should not take these drugs

About Kailera Therapeutics Kailera Therapeutics (Kailera) is an advanced clinical-stage biotechnology company focused on elevating the next era of obesity care by progressing a diversified pipeline to provide options for people living with obesity no matter where they are in their treatment journey

The drug performed better on all secondary endpoints as well, including a greater percentage of people losing at least 15% of their weight (roughly a third of those on the highest dose achieved this)