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The company expects this pricing change to have only a "low single digit" negative impact on its 2026 global sales growth, with semaglutide sales still projected to rise from $33 billion in 2025 to roughly $36 billion in 2026

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Studies focused on traumatic brain injury recovery and aging models have used 48-hour interval protocols effectively, suggesting this represents near the minimum frequency that maintains cumulative neuroplastic stimulus

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