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Compared to chow controls, Ppara expression was significantly down-regulated in ANT, Ppard not regulated, and Pparg upregulated in ANT (Fig

Plasma total GLP-1 levels were measured by radioimmunoassay using GLPIT-36HK (Millipore, USA), with a sensitivity of 3 pmol/l and intra- and interassay CVs of 7.9% and 12.9%

Its primary indication remains weight management, though the metabolic improvements associated with weight loss may have secondary effects on various body systems, including reproductive health

The US Food and Drug Administration (FDA) has similarly been investigating reports of suicidal thoughts in patients taking GLP-1 receptor agonists for weight management and diabetes, though no definitive causal relationship has been established

1999 Oct;4(5):330-41