Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]
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Diabetologia 62 (9), 15391549
Inhibition of Gln metabolism significantly reduces cFLIP levels, leading to the formation of the death-inducing signaling complex mediated by TRAIL
The peptide demonstrates efficacy even when healing is compromised by concurrent corticosteroid administration, a significant advantage given that corticosteroids are commonly prescribed anti-inflammatory medications that typically impair tissue repair
