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One-carbon metabolism and the transsulfuration pathway contain many allosteric interactions by which substrates in one part of the pathway affect the activity of distant enzymes

The NAD + precursor NR is also metabolized through salvage, but is first phosphorylated by nicotinamide riboside kinase 1 or 2 (NRK1/2) into NMN 27

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PROTO1 provides robust protection against kanamycin-induced hearing loss in rats, in Proceedings of the Association for Research in Otolaryngology Annual Meeting (Baltimore, MD)