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Description

Cancer 55 , 126131 (2006)

Smits RM, Veldhuijzen DS, Wulffraat NM, Evers AWM

Some patients may achieve adequate glycemic control or weight loss at this dose level, particularly those with mild metabolic dysfunction or those who are particularly sensitive to the medications effects

Specifically, EGFR activation triggers ERK-mediated phosphorylation and nuclear translocation of ACSS2, which binds to KAT2A, functioning as a lactyltransferase to promote H3K14/18la and facilitating Wnt/b-catenin, NF-kB, and PD-L1 expression