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Oncogene 39 , 11401151 (2020)
GHK-Cu upregulates genes involved in collagen synthesis, extracellular matrix assembly, and tissue remodeling while downregulating genes associated with tissue destruction (matrix metalloproteinases, inflammatory cytokines)
This reprogramming involves the downregulation of genes associated with proinflammatory responses and resistance to tissue invasion, along with the upregulation of genes that enhance cell proliferation, promote tolerance, and support tissue invasion (Yang et al., 2022)
It provides a way to support patients who struggle with diet-resistant fat
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