Overdosing can lead to adverse glutathione injection side effects, including serious complications like kidney dysfunction or toxic epidermal necrolysis
Rodrgues et al
In order to extract second-order rate constants, the model thioester and the Cys peptides were reacted at a respective concentration of 0.1 and 0.15 mM (in phosphate buffer 0.1 M, 6 M Gn.HCl, 200 mM MPAA, 100 mM TCEP, pH 7.2, 37 C)
These follow-on patents form a systematic attempt to add barriers of entry for generic competitors, with the intention of extending Novo Nordisks market monopoly for as long as possible when the main compound patent on the underlying active ingredient, semaglutide, expires
Drug Delivery and Translational Research , 12 (7), 16591683